Gongylonema neoplasticum

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Gongylonema neoplasticum
Scientific classification
Kingdom: Animalia
Phylum: Nematoda
Class: Secernentea
Order: Spirurida
Suborder: Spirurina
Superfamily: Spiruroidea
Family: Gongylonematidae
Genus: Gongylonema
Species: G. neoplasticum
Binomial name
Gongylonema neoplasticum
Fibiger & Ditlevsen, 1914

Gongylonema neoplasticum is a species of nematode.[1]

It was previously known as Spiroptera carcinoma. Under this name, it was the basis of the research that won Johannes Fibiger the 1926 Nobel Prize in Physiology or Medicine.

His research indicated that nematode infection led reliably to gastric tumors in rats, and this finding was one of the first demonstrations that an infection could be a carcinogen.

His work was later reappraised, and current consensus is that while the worms stimulated previously damaged cells to form tumors, the worms themselves were not carcinogenic to healthy cells.

It has also been known as "spiroptera neoplasticum".[2]

A similar parasite, Spirocerca lupi, can cause oesophageal cancer in dogs.


  1. ^ Paramasvaran S, Sani RA, Hassan L, et al. (April 2009). "Endo-parasite fauna of rodents caught in five wet markets in Kuala Lumpur and its potential zoonotic implications" (PDF). Trop Biomed 26 (1): 67–72. PMID 19696729. 
  2. ^ HITCHCOCK CR, BELL ET (June 1952). "Studies on the nematode parasite, Gongylonema neoplasticum (spiroptera neoplasticum), and avitaminosis A in the forestomach of rats: comparison with Fibiger's results". J. Natl. Cancer Inst. 12 (6): 1345–87. doi:10.1093/jnci/12.6.1345. PMID 14939031. 

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