Antonie van Leeuwenhoek

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This is a Dutch name; the family name is Van Leeuwenhoek, not Leeuwenhoek.
Antonie van Leeuwenhoek
Jan Verkolje - Antonie van Leeuwenhoek.jpg
Portrait of Antonie van Leeuwenhoek (1632–1723) by Jan Verkolje
Born (1632-10-24)October 24, 1632
Delft, Dutch Republic
Died August 26, 1723(1723-08-26) (aged 90)
Delft, Dutch Republic
Residence Netherlands
Nationality Dutch
Fields Microscopist and Biologist

Antonie Philips van Leeuwenhoek[note 1] (/ˈlvənhʊk/, Dutch: [ɑnˈtoːni vɑn ˈleːuə(n)ˌɦuk]; October 24, 1632 – August 26, 1723) was a Dutch tradesman and scientist. He is commonly known as "the Father of Microbiology", and considered to be the first microbiologist. He is best known for his work on the improvement of the microscope and for his contributions towards the establishment of microbiology.

Raised in Delft, Netherlands, Van Leeuwenhoek worked as a draper in his youth, and founded his own shop in 1654. He made a name for himself in municipal politics, and eventually developed an interest in lensmaking. Using his handcrafted microscopes, he was the first to observe and describe microorganisms, which he originally referred to as animalcules. Most of the "animalcules" are now referred to as unicellular organisms though he observed multicellular organisms in pond water. He was also the first to document microscopic observations of muscle fibers, bacteria, spermatozoa, and blood flow in capillaries (small blood vessels). Van Leeuwenhoek did not author any books; his discoveries came to light through correspondence with the Royal Society, which published his letters.

Early life and career

William Davidson had appointed Van Leeuwenhoek in 1648 as his assistant. Van Leeuwenhoek left after six years.[2][3] (Portrait by Abraham van den Tempel, 1664)

Antonie van Leeuwenhoek was born in Delft, Dutch Republic, on October 24, 1632. On 4 November he was baptized as Thonis. His father, Philips Antonisz van Leeuwenhoek, was a basket maker who died when Antonie was only five years old. His mother, Margaretha (Bel van den Berch), came from a well-to-do brewer's family, and remarried Jacob Jansz Molijn, a painter. Antonie had four older sisters, Margriet, Geertruyt, Neeltje, and Catharina.[4] When he was around ten years his step-father died. He attended school in Warmond for a short time before being sent to live in Benthuizen with his uncle, an attorney. At the age of 16 he became a bookkeeper's apprentice at a linen-draper's shop in Amsterdam[5] owned by the Scottish William Davidson.

Van Leeuwenhoek married Barbara de Mey in July 1654, with whom he would have one surviving daughter, Maria (four other children died in infancy). That same year he returned to Delft, where he would live and study for the rest of his life. He opened a draper's shop, which he ran throughout the 1650s. His wife died in 1666, and in 1671 Van Leeuwenhoek remarried, to Cornelia Swalmius, with whom he had no children.[6] His status in Delft had grown throughout the years. In 1660 he received a lucrative job as chamberlain for the Delft sheriffs' assembly chamber in the City Hall, a position which he would hold for almost 40 years. In 1669 he was appointed as a land surveyor by the Court of Holland; at some time he combined it with another municipal job, being the official "wine-gauger" of Delft and in charge of the city's wine imports[7] and (wine) taxation.

Van Leeuwenhoek was a contemporary of another famous Delft citizen, the painter Johannes Vermeer, who was baptized just four days earlier. It has been suggested that he is the man portrayed in two of Vermeer's paintings of the late 1660s, The Astronomer and The Geographer. However, others argue that there appears to be little physical similarity. Because they were both relatively important men in a city with only 24,000 inhabitants, it is likely that they were at least acquaintances, because Van Leeuwenhoek acted as the executor of Vermeer's will, after the painter died in 1675.[8][note 2]

Microscopic study

While running his draper's shop, Van Leeuwenhoek wanted to see the quality of the thread, better than the then-current magnifying lenses available. Therefore, he began to develop an interest in lensmaking, although few records exist of his early activity. Van Leeuwenhoek's interest in microscopes and a familiarity with glass processing led to one of the most significant, and simultaneously well-hidden, technical insights in the history of science. By placing the middle of a small rod of soda lime glass in a hot flame, Van Leeuwenhoek could pull the hot section apart to create two long whiskers of glass. Then, by reinserting the end of one whisker into the flame, he could create a very small, high-quality glass sphere. These spheres became the lenses of his microscopes, with the smallest spheres providing the highest magnifications.

Microscopic section through one-year-old ash tree (Fraxinus) wood, drawing made by Van Leeuwenhoek.

Recognition by the Royal Society

After developing his method for creating powerful lenses and applying them to the study of the microscopic world, Van Leeuwenhoek introduced his work to his friend, the prominent Dutch physician Reinier de Graaf. When the Royal Society in London published the groundbreaking work of an Italian lensmaker in their journal Philosophical Transactions of the Royal Society, De Graaf wrote to the journal's editor Henry Oldenburg with a ringing endorsement of Van Leeuwenhoek's microscopes which, he claimed, "far surpass those which we have hitherto seen". In response the Society published in 1673 a letter from Van Leeuwenhoek, which included his microscopic observations on mold, bees, and lice.[9]

Letter of 1677 from Leeuwenhoek to Oldenburg, with the latter's English translation behind. The full correspondence remains in the Royal Society Library.

Van Leeuwenhoek's work fully captured the attention of the Royal Society, and he began regularly corresponding with the Society regarding his observations. At first he had been reluctant to publicize his findings, regarding himself as a businessman with little scientific, artistic, or writing background, but De Graaf urged him to be more confident in his work.[10] When Van Leeuwenhoek died in 1723, he had written some 190 letters to the Royal Society, detailing his findings in a wide variety of fields, centered on his work in microscopy. He only wrote letters, in his own colloquial flavor of Dutch; he never published a proper scientific paper. He strongly preferred to work alone, distrusting the sincerity of those who offered their assistance.[11] The letters were translated into Latin or English by Henry Oldenburg, who had learned Dutch in order to be able to do so.

Despite the initial success of Van Leeuwenhoek's relationship with the Royal Society, this relationship was soon severely strained. In 1676, his credibility was questioned when he sent the Royal Society a copy of his first observations of microscopic single-celled organisms. Previously, the existence of single-celled organisms was entirely unknown. Thus, even with his established reputation with the Royal Society as a reliable observer, his observations of microscopic life were initially met with both skepticism and open ridicule.[12] Eventually, in the face of Van Leeuwenhoek's insistence, the Royal Society arranged for Alexander Petrie, minister to the English Reformed Church in Delft, Benedict Haan, at that time Lutheran minister at Delft, and Henrik Cordes, then Lutheran minister at the Hague, accompanied by Sir Robert Gordon and four others to determine whether it was in fact Van Leeuwenhoek's ability to observe and reason clearly, or perhaps the Royal Society's theories of life itself that might require reform. Finally in 1677 [13] Van Leeuwenhoek's observations were fully vindicated by the Royal Society.[14]

Antonie van Leeuwenhoek was elected to the Royal Society in February 1680 on the nomination of William Croone, a then-prominent physician.[note 3] Van Leeuwenhoek was "taken aback" by the nomination, which he considered a high honor, although he did not attend the induction ceremony in London, nor did he ever attend a Royal Society meeting.[16]

Scientific fame

By the end of the 17th century, Van Leeuwenhoek had a virtual monopoly on microscopic study and discovery. His contemporary Robert Hooke, an early microscope pioneer, bemoaned that the field had come to rest entirely on one man's shoulders.[17] He was visited over the years by many notable individuals, such as Russian Tsar Peter the Great. To the disappointment of his guests, Leeuwenhoek refused to reveal the cutting-edge microscopes he relied on for his discoveries, instead showing visitors a collection of average-quality lenses.[18] An experienced businessman, Van Leeuwenhoek realized that if his simple method for creating the critically important lens was revealed, the scientific community of his time would likely disregard or even forget his role in microscopy. He therefore allowed others to believe that he was laboriously spending most of his nights and free time grinding increasingly tiny lenses to use in microscopes, even though this belief conflicted both with his construction of hundreds of microscopes and his habit of building a new microscope whenever he chanced upon an interesting specimen that he wanted to preserve. He made about 200 microscopes with different magnification.

Van Leeuwenhoek was visited by Leibniz, William III of Orange and his wife, the burgemeester (the mayor) Johan Huydecoper of Amsterdam, the latter being very interested in collecting and growing plants for the Hortus Botanicus Amsterdam and all gazed at the tiny creatures. Nicolaes Witsen sent him a map of Tartaria and a mineral found near the origin of the river Amur.[19] In 1698 Van Leeuwenhoek was invited to visit the Tsar Peter the Great in his boat. On this occasion Van Leeuwenhoek presented the Tsar an "eel-viewer", so Peter could study the blood circulation, whenever he wanted.

Techniques and discoveries

Leeuwenhoek's microscopes by Henry Baker

Antonie van Leeuwenhoek made more than 500 optical lenses. He also created at least 25 single-lens microscopes, of differing types, of which only nine survived. These microscopes were made of silver or copper frames, holding hand-made lenses. Those that have survived are capable of magnification up to 275 times. It is suspected that Van Leeuwenhoek possessed some microscopes that could magnify up to 500 times. Although he has been widely regarded as a dilettante or amateur, his scientific research was of remarkably high quality.[20]

The single-lens microscopes of Van Leeuwenhoek were relatively small devices, the biggest being about 5 cm long.[21] They are used by placing the lens very close in front of the eye, while looking in direction of the sun. The other side of the microscope had a pin, where the sample was attached in order to stay close to the lens. There were also three screws that allowed to move the pin, and the sample, along three axes: one axis to change the focus, and the two other axes to navigate through the sample.

Van Leeuwenhoek maintained throughout his life that there are aspects of microscope construction "which I only keep for myself", in particular his most critical secret of how he made the lenses. For many years no-one was able to reconstruct Van Leeuwenhoek's design techniques. However, in 1957 C.L. Stong used thin glass thread fusing instead of polishing, and successfully created some working samples of a Van Leeuwenhoek design microscope.[22] Such a method was also discovered independently by A. Mosolov and A. Belkin at the Russian Novosibirsk State Medical Institute.[23]

Replica of microscope by Leeuwenhoek

Van Leeuwenhoek used samples and measurements to estimate numbers of microorganisms in units of water.[24][25] He also made good use of the huge lead provided by his method. He studied a broad range of microscopic phenomena, and shared the resulting observations freely with groups such as the British Royal Society.[26] Such work firmly established his place in history as one of the first and most important explorers of the microscopic world. Antonie van Leeuwenhoek was one of the first people to observe cells, much like Robert Hooke.

Van Leeuwenhoek's main discoveries are:

In 1687 Van Leeuwenhoek reported his research on the coffee bean. He roasted the bean, cut it into slices and saw a spongeous interior. The bean was pressed, and an oil appeared. He boiled the coffee with rain water twice, set it aside.[28]

Like Robert Boyle and Nicolaas Hartsoeker, Van Leeuwenhoek was interested in the dried cochineal, trying to find out if the dye came from a berry or an insect.[29][30][31]

Antonie van Leeuwenhoek's religion was "Dutch Reformed" Calvinist.[32] He often referred with reverence to the wonders God designed in making creatures great and small. He believed that his amazing discoveries were merely further proof of the great wonder of God's creation.[33][34] Van Leeuwenhoek's discovery that smaller organisms procreate similarly to larger organisms challenged the contemporary belief, generally held by the 17th century scientific community, that such organisms generated spontaneously. The position of the Church on the exact nature of the spontaneous generation of smaller organisms was ambivalent.[citation needed]

Death and legacy

Antonie van Leeuwenhoek is buried in the Oude kerk in Delft

By the end of his life, Van Leeuwenhoek had written approximately 560 letters to the Royal Society and other scientific institutions concerning his observations and discoveries. Even during the last weeks of his life, Van Leeuwenhoek kept sending letters full of observations to London. The last few contained a precise description of his own illness. He suffered from a rare disease, an uncontrolled movement of the midriff, which is now named Van Leeuwenhoek's disease.[35] He died at the age of 90, on August 26, 1723 and was buried four days later in the Oude Kerk (Delft).

In 1981 the British microscopist Brian J. Ford found that Van Leeuwenhoek's original specimens had survived in the collections of the Royal Society of London.[36] They were found to be of high quality, and were all well preserved. Ford carried out observations with a range of single-lens microscopes, adding to our knowledge of Van Leeuwenhoek's work.

See also


  1. ^ The spelling of Leeuwenhoek's name is exceptionally varied. He was christened as Thonis, but always went by Antonj (corresponding with the English Antony). The final j of his given name is the Dutch tense i. Until 1683 he consistently used the spelling Antonj Leeuwenhoeck (ending in –eck) when signing his letters. Throughout the mid-1680s he experimented with the spelling of his name, and after 1685 settled on the most recognized spelling van Leeuwenhoek.[1]
  2. ^ In A Short History of Nearly Everything (p. 236) Bill Bryson alludes to rumors that Vermeer's mastery of light and perspective came from use of a camera obscura produced by Leeuwenhoek. This is one of the examples of the controversial Hockney–Falco thesis, which claims that some of the Old Masters used optical aids to produce their masterpieces.
  3. ^ He was also nominated as a "corresponding member" of the French Academy of Sciences in 1699, but there is no evidence that the nomination was accepted nor that he was ever aware of it.[15]
  4. ^ A disease in the city of Kampen, Netherlands (1736), which originated (caused) by "little animals". These 'bloedloze dieren' (bloodless animals, the Invertebrata) are — most likely — the little animals described in the work of Antonie van Leeuwenhoek (Evert Valk, a physician about an epidemic in the city of Kampen during the year 1736)


  1. ^ Dobell, pp. 300–305.
  2. ^ The curious observer. Events of the first half of van Leeuwenhoek's life. Lens on Leeuwenhoek (2009-09-01). Retrieved on 2013-04-20.
  3. ^ Huerta, p. 31.
  4. ^ Dobell, pp. 19–21.
  5. ^ Dobell, pp. 23–24.
  6. ^ Dobell, pp. 27–31.
  7. ^ Dobell, pp. 33–37.
  8. ^ Van Berkel, K. (February 24, 1996). Vermeer, Van Leeuwenhoek en De Astronoom. Vrij Nederland (Dutch magazine), p. 62–67.
  9. ^ Dobell, pp. 37–41.
  10. ^ Dobell, pp. 41–42.
  11. ^ Dobell, pp. 43–44.
  12. ^ "Letter from the Secretary of the Royal Society, London, to Van Leeuwenhoek" (PDF). 20 October 1676. Dear Mr. Anthony van Leeuwenhoek, Your letter of October 10th has been received here with amusement. Your account of myriad "little animals" seen swimming in rainwater, with the aid of your so-called "microscope," caused the members of the society considerable merriment when read at our most recent meeting. Your novel descriptions of the sundry anatomies and occupations of these invisible creatures led one member to imagine that your "rainwater" might have contained an ample portion of distilled spirits—imbibed by the investigator. Another member raised a glass of clear water and exclaimed, "Behold, the Africk of Leeuwenhoek." For myself, I withhold judgment as to the sobriety of your observations and the veracity of your instrument. However, a vote having been taken among the members (accompanied, I regret to inform you, by considerable giggling) it has been decided not to publish your communication in the Proceedings of this esteemed society. However, all here wish your "little animals" health, prodigality and good husbandry by their ingenious "discoverer"." 
  13. ^ Schierbeek, A.: "The Disbelief of the Royal Society." Measuring the Invisible World. London and New York: Abelard-Schuman, 1959. N. pag. Print.
  14. ^ Full text of "Antony van Leeuwenhoek and his "Little animals"; being some account of the father of protozoology and bacteriology and his multifarious discoveries in these disciplines;". Retrieved on 2013-04-20.
  15. ^ Dobell, pp. 53–54.
  16. ^ Dobell, pp. 46–50.
  17. ^ Dobell, pp. 52–53.
  18. ^ Dobell, pp. 54–61.
  19. ^ Driessen, J. (1996) Tsaar Peter de Grote en zijn Amsterdamse vrienden, Kosmos - Zomer & Keunig , pp. 35, 95, 96, ISBN 90-215-2829-0.
  20. ^ Brian J. Ford (1992). "From Dilettante to Diligent Experimenter: a Reappraisal of Leeuwenhoek as microscopist and investigator". Biology History 5 (3). 
  21. ^ Lens on Leeuwenhoek: How he made his tiny microscopes., retrieved 2013-09-15.
  22. ^ "A glass-sphere microscope". Archived from the original on 11 June 2010. Retrieved 2010-06-13. 
  23. ^ A. Mosolov & A. Belkin (1980). "Secret of Antony van Leeuwenhoek?". Nauka i Zhizn (Science and Life). 09-1980: 80–2. 
  24. ^ F. N. Egerton (1967). "Leeuwenhoek as a founder of animal demography". Journal of the History of Biology 1: 1–22. doi:10.1007/BF00149773. JSTOR 4330484. 
  25. ^ Frank N. Egerton (2006). "A History of the Ecological Sciences, Part 19: Leeuwenhoek's Microscopic Natural History". Bulletin of the Ecological Society of America 87: 47. doi:10.1890/0012-9623(2006)87[47:AHOTES]2.0.CO;2. 
  26. ^ "Robert Hooke (1635–1703)". Retrieved 2010-06-13. 
  27. ^ Pommerville, Jeffrey (2014). Fundamentals of microbiology. Burlington, MA: Jones & Bartlett Learning. p. 6. ISBN 978-1-4496-8861-5. 
  28. ^ May 9, 1687, Missive 54.
  29. ^ Antoni van Leeuwenhoek; Samuel Hoole (1800). The Select Works of Antony Van Leeuwenhoek, Containing His Microscopical Discoveries in Many of the Works of Nature. G. Sidney. pp. 213–. 
  30. ^ Rocky Road: Leeuwenhoek. (2012-11-22). Retrieved on 2013-04-20.
  31. ^ Greenfield, Amy Butler (2005). A Perfect Red: Empire, Espionage, and the Quest for the Color of Desire. New York: Harper Collins Press. ISBN 0-06-052276-3
  32. ^ "The religious affiliation of Biologist A. van Leeuwenhoek". 2005-07-08. Archived from the original on 7 July 2010. Retrieved 2010-06-13. 
  33. ^ "The Religion of Antony van Leeuwenhoek". 2006. Archived from the original on 4 May 2006. Retrieved 2006-04-23. 
  34. ^ A. Schierbeek, Editor-in-Chief of the Collected Letters of A. van Leeuwenhoek, Measuring the Invisible World: The Life and Works of Antoni van Leeuwenhoek F R S, Abelard-Schuman (London and New York, 1959), QH 31 L55 S3, LC 59-13233. This book contains excerpts of Van Leeuwenhoek's letters and focuses on his priority in several new branches of science, but makes several important references to his spiritual life and motivation.
  35. ^ Life and work of Antoni van Leeuwenhoek of Delft in Holland; 1632–1723 (1980) Published by the Municipal Archives Delft, p. 9
  36. ^ "The discovery by Brian J Ford of Leeuwenhoek's original specimens, from the dawn of microscopy in the 16th century". Retrieved 2010-06-13. 


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